Back to search

Article

OptoDyCE-plate as an affordable high throughput imager for all optical cardiac electrophysiology

2023-08-31

Abstract excerpt

We present a simple low-cost system for comprehensive functional characterization of cardiac function under spontaneous and paced conditions, in standard 96 and 384-well plates. This full-plate actuator/imager, OptoDyCE-plate, uses optogenetic stimulation and optical readouts of voltage and calcium from all wells in parallel. The system is validated with syncytia of human induced pluripotent stem cell derived card...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4d4ee468-0d51-5ecc-a679-73cca7cc79c3
DOI
10.1101/2023.08.29.555447
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
OptoDyCE-plate as an affordable high throughput imager for all optical cardiac electrophysiologyDOI 10.1101/2023.08.29.555447
INTEGRATION OF ENGINEERED “SPARK-CELL” SPHEROIDS FOR OPTICAL PACING OF CARDIAC TISSUESemantic proximity
CRISPRi Gene Modulation and All-Optical Electrophysiology in Post-Differentiated Human iPSC-CardiomyocytesSemantic proximity
Robotic manipulation of cardiomyocytes to identify gap junction modifiers for arrhythmogenic cardiomyopathy.Semantic proximity
3D Spatiotemporal Activation Mapping of Cardiac Organoids Using Conformal Shell Microelectrode Arrays (MEAs)Semantic proximity
Industrialization of three-dimensional hiPSC-cardiac microtissues for high-throughput cardiac safety and drug discovery screeningSemantic proximity
High-Throughput Phenotyping of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Neurons Using Electric Field Stimulation and High-Speed Fluorescence Imaging.Semantic proximity
Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics.Semantic proximity
Engineered developmental niche enables predictive phenotypic screening in human dystrophic cardiomyopathySemantic proximity
Simultaneous widefield voltage and interferometric dye-free optical mapping quantifies electromechanical waves in human iPSC-cardiomyocytesSemantic proximity
MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.Semantic proximity
Optical modulation of excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytesSemantic proximity
Dynamic Electrical Stimulation Promotes hiPSC-CM Differentiation and FunctionalitySemantic proximity
Select a neighboring publication to make it the new centre.