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Article

hERG-deficient human embryonic stem cell-derived cardiomyocytes for modelling QT prolongation

7 May 2021

Abstract excerpt

BACKGROUND: Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclear. In this study, we generated an hERG-deficient human cardiomyocyte (CM) model that simulates 'human homozygous hERG mutations' to explore the underlying impact of hERG...

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PMID: 33962658
DOI: 10.1186/s13287-021-02346-1

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