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FiMO: Inferring the Temporal Order of Mutations on Clonal Phylogeny under Finite-sites Models

2022-01-24

Abstract excerpt

Determining the temporal order of somatic mutations that drives cancer progression is essential for understanding the intra-tumor heterogeneity (ITH) and designing personalized therapy. Recently emerged single-cell DNA sequencing (SCS) technologies provide high-resolution datasets suitable for elucidating the temporal order of mutation. However, this task is challenged by technical artifacts associated with single...

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Literature Corpus work: d2b8e42f-510e-5dc2-9b92-7f0925456409
DOI: 10.1101/2022.01.23.477444

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