Article

Predicting T Cell Receptor Functionality against Mutant Epitopes

2023-05-12

Abstract excerpt

Cancer cells or pathogens can escape recognition by T cell receptors (TCRs) through mutations of immunogenic epitopes. TCR cross-reactivity, i.e., recognition of multiple epitopes with sequence similarities, can be a factor to counteract such mutational escape. However, cross-reactivity of cell-based immunotherapies may also cause severe side effects when self-antigens are targeted. Therefore, the ability to predi...

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Literature Corpus work: 2a66ee2d-dd0b-548f-8860-4dec0365b109
DOI: 10.1101/2023.05.10.540189

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