Model-guided gene circuit design for engineering genetically stable cell populations in diverse applications.

Abstract excerpt

Maintaining engineered cell populations' genetic stability is a key challenge in synthetic biology. Synthetic genetic constructs compete with a host cell's native genes for expression resources, burdening the cell and impairing its growth. This creates a selective pressure favouring mutations which alleviate this growth defect by removing synthetic gene expression. Non-functional mutants thus spread in cell...

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• Gene Regulatory Networks
• Genetic Engineering
• Models, Genetic
• Mutation
• Synthetic Biology