Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary regain of lost gene circuit function.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2019

Kheir Gouda Mirna, Manhart Michael, Balázsi Gábor

Abstract excerpt

Evolutionary reversibility-the ability to regain a lost function-is an important problem both in evolutionary and synthetic biology, where repairing natural or synthetic systems broken by evolutionary processes may be valuable. Here, we use a synthetic positive-feedback (PF) gene circuit integrated into haploid Saccharomyces cerevisiae cells to test if the population can restore lost PF function. In previous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Gene Regulatory Networks
Share to Genetic Fitness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Synthetic Biology

Source

Open in PubMed Open full text

Identifiers

PMID: 31754027
DOI: 10.1073/pnas.1912257116
PMCID: PMC6911209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary regain of lost gene circuit function.PMID 31754027Read ↗

Adaptation of the yeast gene knockout collection is near-perfectly predicted by fitness and diminishing return epistasis.Semantic proximity Read ↗

Evolverator: An engineered yeast system to drive rapid continuous <i>in vivo</i> evolution of proteinsSemantic proximity Read ↗

Adaptation of the yeast gene knockout collection is near-perfectly predicted by fitness and diminishing return epistasisSemantic proximity Read ↗

Building synthetic systems to learn nature's design principles.Semantic proximity Read ↗

Induced mutations in yeast cell populations adapting to an unforeseen challenge.Semantic proximity Read ↗

Robustness and evolvability in natural chemical resistance: identification of novel systems properties, biochemical mechanisms and regulatory interactions.Semantic proximity Read ↗

Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network.Semantic proximity Read ↗

Model-guided gene circuit design for engineering genetically stable cell populations in diverse applications.Semantic proximity Read ↗

Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds.Semantic proximity Read ↗

Programming adaptive control to evolve increased metabolite production.Semantic proximity Read ↗

A high-resolution two-step evolution experiment in yeast reveals a shift from pleiotropic to modular adaptation.Semantic proximity Read ↗

Experimental evolution for the recovery of growth loss due to genome reduction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.