Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo continuous evolution of genes and pathways in yeast.

Nature communications - 17 Oct 2016

Crook Nathan, Abatemarco Joseph, Sun Jie, Wagner James M, Schmitz Alexander, Alper Hal S

Abstract excerpt

Directed evolution remains a powerful, highly generalizable approach for improving the performance of biological systems. However, implementations in eukaryotes rely either on in vitro diversity generation or limited mutational capacities. Here we synthetically optimize the retrotransposon Ty1 to enable in vivo generation of mutant libraries up to 1.6 × 107 l-1 per round, which is the highest of any in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Directed Molecular Evolution
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Library

Share to Kluyveromyces

Share to Metabolic Networks and Pathways

Share to Mutagenesis, Insertional

Share to Retroelements

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 27748457
DOI: 10.1038/ncomms13051
PMCID: PMC5071640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo continuous evolution of genes and pathways in yeast.PMID 27748457Read ↗

A synthetic RNA-mediated evolution system in yeast.Semantic proximity Read ↗

Advances in in vivo continuous evolution technologies for strain development and enzyme engineering.Semantic proximity Read ↗

A synthetic RNA-mediated evolution system in yeastSemantic proximity Read ↗

Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods.Semantic proximity Read ↗

The evolving art of creating genetic diversity: From directed evolution to synthetic biology.Semantic proximity Read ↗

Multiplex genome editing by natural transformation.Semantic proximity Read ↗

CasPER, a method for directed evolution in genomic contexts using mutagenesis and CRISPR/Cas9.Semantic proximity Read ↗

The developing toolkit of continuous directed evolution.Semantic proximity Read ↗

Inducible directed evolution of complex phenotypes in bacteria.Semantic proximity Read ↗

Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes.Semantic proximity Read ↗

Compartmentalized partnered replication for the directed evolution of genetic parts and circuits.Semantic proximity Read ↗

Enhancing Cellular and Enzymatic Properties Through In Vivo Continuous Evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.