Article

High-throughput discovery of transmembrane helix dimers from human single-pass membrane proteins with TOXGREEN sort-seq

2025-04-26

Abstract excerpt

The oligomerization of the transmembrane helices of single-pass membrane proteins is crucial to biological function and its misregulation can lead to many diseases. The study of transmembrane helix oligomerization is facilitated by the availability of genetic reporter assays, which are essential tools for understanding the organization and biology of single-pass systems. In particular, reporter assays are crucial...

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Literature Corpus work: e61e41a0-7c83-58ab-9cb8-b7e4b1171016
DOI: 10.1101/2025.04.22.650048

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