Article

Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection

2021-02-23

Abstract excerpt

<title>Abstract</title> <p>The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense RNA virus. How the host immune system senses and responds to SARS-CoV-2 infection remain to be determined. Here, we report that SARS-CoV-2 infection activates the innate immune response through the cytosolic DNA sensing cGAS-STING pathway. S...

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Literature Corpus work: e60c1cbf-fdcc-5457-ba50-c4ad89f35b99
DOI: 10.21203/rs.3.rs-235742/v1

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