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SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response

12 Apr 2022

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the unprecedented coronavirus disease 2019 (COVID-19) pandemic. Critical cases of COVID-19 are characterized by the production of excessive amounts of cytokines and extensive lung damage, which is partially caused by the fusion of SARS-CoV-2–infected pneumocytes. Here, we found that cell fusion caused by the SARS-CoV-2 spike (S) protein induced a...

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PMID: 35412852
DOI: 10.1126/scisignal.abg8744

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