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Article

Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection

3 Nov 2021

Abstract excerpt

The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense RNA virus. How the host immune system senses and responds to SARS-CoV-2 infection remain largely unresolved. Here, we report that SARS-CoV-2 infection activates the innate immune response through the cytosolic DNA sensing cGAS-STING pathway. SARS-CoV-2 infection...

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PMID: 34732709
DOI: 10.1038/s41392-021-00800-3

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