Chromatin accessibility profiling in tissue sections by spatial ATAC

Abstract excerpt

Current methods for epigenomic profiling are limited in the ability to obtain genome wide information with spatial resolution. Here we introduce spatial ATAC, a method that integrates transposase-accessible chromatin profiling in tissue sections with barcoded solid-phase capture to perform spatially resolved epigenomics. We show that spatial ATAC enables the discovery of the regulatory programs underlying spatial...

Topics

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• Fetal Development
• Chromatin Immunoprecipitation Sequencing
• Datasets as Topic
• Disease
• Enhancer Elements, Genetic
• Molecular Sequence Annotation
• Regulatory Sequences, Nucleic Acid
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

ba6f5b92-2966-507d-ad32-940e8f34392e

DOI

10.1101/2022.07.27.500203