Article

ASO targeting temperature-controlled <i>RBM3</i> poison exon splicing prevents neurodegeneration in vivo

2022-10-26

Abstract excerpt

<h4>Summary</h4> Neurodegenerative diseases are increasingly prevalent in the aging population, yet currently no disease-modifying treatments are available. Increasing the expression of the cold-shock protein, RBM3, through therapeutic hypothermia is remarkably neuroprotective, but cooling poses a health risk itself, strongly limiting its clinical application. Selective upregulation of RBM3 at normothermia thus h...

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Literature Corpus work: e5ed7707-1f5b-51fc-bca8-58be336a9bd7
DOI: 10.1101/2022.10.26.513170

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