Article

Stabilizing mammalian RNA thermometer confers neuroprotection in subarachnoid hemorrhage

2024-05-17

Abstract excerpt

<h4>Summary</h4> Mammals tightly regulate their core body temperature, yet how cells sense and respond to small temperature changes at the molecular level remains incompletely understood. Here, we discover a significant enrichment of RNA G-quadruplex (rG4) motifs around splice sites of cold-repressed exons. These thermosensing RNA structures, when stabilized, mask splice sites, reducing exon inclusion. Focusing o...

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Literature Corpus work: 2cda75a1-1e10-5629-9142-011c18b1712a
DOI: 10.1101/2024.05.17.594628

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