Article

Cold induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm

2020-06-06

Abstract excerpt

Cooling patients to sub-physiological temperatures is an integral part of modern medicine. We show that cold exposure induces temperature-specific changes to the higher-order chromatin and gene expression profiles of human cells. These changes are particularly dramatic at 18°C, a temperature synonymous with that experienced by patients undergoing controlled deep-hypothermia during surgery. Cells exposed to 18°C ex...

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Literature Corpus work: 54eeda1e-8b68-5709-8b8b-76bd58080027
DOI: 10.1101/2020.06.05.127290

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