Article

An optimized “hypoxia in a pill” regimen reverses neurodegenerative disease phenotypes in multiple preclinical models

2026-07-03

Abstract excerpt

A growing body of pre-clinical research has demonstrated the therapeutic potential of chronic, continuous hypoxia (11% FIO2) for treating both rare and common forms of neurodegeneration (1). However, the chronic delivery of hypoxic gas poses both practical challenges and long-term safety concerns. We previously introduced a small molecule, “hypoxia-in-a-pill” regimen that combines the hemoglobin affinity enhancer...

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Literature Corpus work: 55cd54d3-c419-5042-bbd7-b3a594c8e50e
DOI: 10.64898/2026.06.30.734089

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