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Article

ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo

22 Mar 2023

Abstract excerpt

Neurodegenerative diseases are increasingly prevalent in the aging population, yet no disease-modifying treatments are currently available. Increasing the expression of the cold-shock protein RBM3 through therapeutic hypothermia is remarkably neuroprotective. However, systemic cooling poses a health risk, strongly limiting its clinical application. Selective upregulation of RBM3 at normothermia thus holds immense...

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PMID: 36946385
DOI: 10.15252/emmm.202217157

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