Article

17β-Estradiol Counteracts Pathological Microtubule Remodeling To Enhance Cardiac Function

2025-01-24

Abstract excerpt

The female-predominate sex hormone 17β-estradiol exerts cardioprotective effects via multiple mechanisms. Available data demonstrate 17β-estradiol modulates microtubule dynamics in vitro , but its effects on pathogenic microtubule remodeling in pressure-overloaded cardiomyocytes are unexplored. Here, we show 17β-estradiol directly blunts microtubule polymerization in vitro , counteracts endothelin-mediated micro...

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Literature Corpus work: e5c70d9b-c17e-537d-ae09-d4dfaa6f48e5
DOI: 10.1101/2025.01.22.634271

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