Article

Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle

2020-06-10

Abstract excerpt

Microtubules tune cytoskeletal stiffness to regulate the mechanics and mechanotransduction of striated muscle. While recent evidence suggests that microtubules enriched in detyrosinated α-tubulin are responsible for these effects in healthy muscle, and for their excess in disease, the possible contribution from several other α-tubulin modifications has not been investigated. Here we used genetic or pharmacologic s...

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Literature Corpus work: 9f6d64e6-dcbc-58d5-bad2-3c2559062788
DOI: 10.1101/2020.06.10.144931

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