Article

Cardiac FGF21 acts as an endocrine suppressor of female fertility in mitochondrial cardiomyopathy

2026-06-01

Abstract excerpt

<title>Abstract</title> <p>Cardiomyopathy is clinically associated with female infertility, yet whether the failing heart directly suppresses reproduction has remained unknown. Here we identify a heart–brain endocrine axis in which pathological cardiac stress induces systemic elevation of the mitokine FGF21, which in turn suppresses the hypothalamic-pituitary-gonadal axis and inhibits fertility. In female mice wi...

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Literature Corpus work: 862bb10b-cfd5-5f6e-994d-9477a19b721b
DOI: 10.21203/rs.3.rs-9548570/v1

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