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Article

A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart.

American journal of physiology. Heart and circulatory physiology - 1 May 2008

Cheng Guangmao, Zile Michael R, Takahashi Masaru, Baicu Catalin F, Bonnema D Dirk, Cabral Fernando, Menick Donald R, Cooper George

Abstract excerpt

Contractile dysfunction in pressure overload-hypertrophied myocardium has been attributed in part to the increased density of a stabilized cardiocyte microtubule network. The present study, the first to employ wild-type and mutant tubulin transgenes in a living animal, directly addresses this microtubule hypothesis by defining the contractile mechanics of the normal and hypertrophied left ventricle (LV) and its...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18344371
DOI: 10.1152/ajpheart.91515.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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