Article

Prion propagation is dependent on key amino acids in Charge cluster 2 within the prion protein

2022-08-09

Abstract excerpt

Prions consist of assemblies of aberrantly folded cellular prion protein (PrP C ) upon template-assisted conversion and propagation of disease-associated PrP. To dissect the N-terminal residues critical for efficient prion propagation, we generated a library of point, double, or triple alanine replacements within residues 23-111 of PrP, stably expressed them in cells silenced for endogenous mouse PrP C and chall...

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Literature Corpus work: 533f2dbc-ef4d-5ea5-a521-40410bc0e50d
DOI: 10.1101/2022.08.08.503133

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