Article

Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies

2020-11-26

Abstract excerpt

Primary cilia are microtubule-based organelles that act as cellular antennae to mediate vertebrate development and growth factor signalling. Defects in primary cilia result in a group of inherited developmental conditions known as ciliopathies. Ciliopathies often present with cystic kidney disease, a major cause of early renal failure that requires renal replacement therapies. Currently, only one drug, Tolvaptan,...

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Literature Corpus work: e5baed02-852f-5953-84f2-1ec2f047b40a
DOI: 10.1101/2020.11.26.393801

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