Article

A shared DNA-repeat toxicity threshold, reached somatically at cell-type-specific rates, unites cortical and striatal neurodegeneration in Huntington’s disease

2025-12-11

Abstract excerpt

Huntington’s disease (HD) affects two major brain areas – the striatum and cerebral cortex – in ways that differ in timing, severity, and gene-expression changes. For these reasons, and because many cortical neurons project axons to the affected striatal neurons, striatal and cortical atrophy have long been proposed to have distinct mechanisms, with one potentially a secondary consequence of the other. In the stri...

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Literature Corpus work: a5176836-137d-5286-9e40-b1a5f885e9e2
DOI: 10.64898/2025.12.09.688862

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