Article

Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting

2022-11-18

Abstract excerpt

<h4>SUMMARY</h4> Pluripotent stem cells (PSCs) provide an unlimited source for generating somatic cell types. However, generating fully mature cells constitutes a bottleneck for realizing their full potential in research and medicine. Here, we report a transcriptional mechanism that governs the timing of cellular maturation in post-mitotic oligodendrocytes. During differentiation of PSCs to oligodendrocytes, the...

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Literature Corpus work: e5826790-32d2-5b36-84fe-a769a225856d
DOI: 10.1101/2022.11.17.516981

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