Article

Charting the transition from in vitro gliogenesis to the in vivo maturation of transplanted human glial progenitor cells

2025-04-22

Abstract excerpt

Neither rodent models nor in vitro studies of human cells adequately describe the molecular ontogeny of human glial progenitor cells (hGPCs). Here, we used scRNA-seq together with scATAC-Seq and CUT&TAG assessment of chromatin availability to track the in vitro genesis and in vivo differentiation of hGPCs from pluripotent stem cells (PSCs). In vitro, the hGPC pool comprised 4 transcriptionally-distinct subpopulati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb072f0b-f6e7-567b-a53f-7e7732a3f973
DOI: 10.1101/2025.04.22.649367

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Charting the transition from in vitro gliogenesis to the in vivo maturation of transplanted human glial progenitor cellsDOI 10.1101/2025.04.22.649367Read

A comprehensive view of cell-type-specific temporal dynamics in human and mouse brainsSemantic proximity Read

Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells.Semantic proximity Read

Developmental landscape of human forebrain at a single-cell level unveils early waves of oligodendrogenesisSemantic proximity Read

Coupled transcriptomic divergence establishes a human-specific synaptic glial precursor stateSemantic proximity Read

Single-Cell Transcriptomic Analysis Reveals Molecular Diversity of Human Oligodendrocyte Progenitor CellsSemantic proximity Read

Comprehensive cell atlas of the first-trimester developing human brainSemantic proximity Read

Molecular and cellular dynamics of the developing human neocortex at single-cell resolutionSemantic proximity Read

Identification of Human Pluripotent Stem Cell Derived Astrocytic Progenitors that Correlate with Glioblastoma SubtypesSemantic proximity Read

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCsSemantic proximity Read

Single-cell RNA-seq supports a developmental hierarchy in human oligodendrogliomaSemantic proximity Read

Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant gliomaSemantic proximity Read

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespanSemantic proximity Read