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Article

Genetic architecture of cancer and other complex diseases: lessons learned and future directions.

Carcinogenesis - 1 Jul 2011

Hindorff Lucia A, Gillanders Elizabeth M, Manolio Teri A

Abstract excerpt

Genome-wide association studies have broadened our understanding of the genetic architecture of cancer to include common variants, in addition to the rare variants previously identified by linkage analysis. We review current knowledge on the genetic architecture of four cancers--breast, lung, prostate and colorectal--for which the balance of common and rare alleles identified ranges from fewer common alleles...

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PMID: 21459759
DOI: 10.1093/carcin/bgr056
PMCID: PMC3140138

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KITLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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