Article
Tissue structure accelerates evolution: premalignant sweeps precede neutral expansion
2019-02-10
Abstract excerpt
Cancer has been hypothesized to be a caricature of the renewal process of the tissue of origin: arising from (and maintained by) small subpopulations capable of continuous growth 1 . The strong influence of the tissue structure has been convincingly demonstrated in intestinal cancers where adenomas grow by the fission of stem-cell-maintained glands influenced by early expression of abnormal cell mobility in cance...
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Identifiers and source
- Literature Corpus work
- e5764607-9a1b-56a9-b42e-5bb17387f6bf
- DOI
- 10.1101/542019