Article

Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function

2023-12-06

Abstract excerpt

Lipid processing by the retinal pigment epithelium (RPE) is necessary to maintain retinal health and function. Dysregulation of retinal lipid homeostasis due to normal aging or to age-related disease triggers lipid accumulation within the RPE, on Bruch’s membrane (BrM), and in the subretinal space. In its role as a hub for lipid trafficking into and out of the neural retina, the RPE packages a significant amount o...

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Identifiers and source

Literature Corpus work: e5442f75-590d-5fb0-b579-d585d5e32f34
DOI: 10.1101/2023.12.06.570418

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