Transcriptomic changes predict metabolic alterations in LC3 associated phagocytosis in aged mice

Abstract excerpt

LC3b ( Map1lc3b ) plays an essential role in canonical autophagy and is one of several components of the autophagy machinery that mediates non-canonical autophagic functions. Phagosomes are often associated with lipidated LC3b, to pro-mote phagosome maturation in a process called LC3-associated phagocytosis (LAP). Specialized phagocytes such as mammary epithelial cells, retinal pigment epithelial (RPE) cells, and...

Topics

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• Apolipoprotein A-I
• Apolipoproteins E
• Autophagy in Disease and Therapy
• Cholesterol and Lipid Metabolism
• Exome Sequencing
• Phagocytosis and Immune Regulation
• Retinal Diseases and Treatments
• Retinal Imaging and Analysis

Identifiers and source

Literature Corpus work

5bfaeee1-5514-5ad6-9d33-fb85823529d2

DOI

10.1101/2023.03.14.532586