Article

MITF is essential for autophagy in the retinal pigment epithelium

2026-05-25

Abstract excerpt

The Microphthalmia-associated transcription factor (MITF) plays a critical role in retinal pigment epithelium (RPE) development and function. Dysfunctional autophagy and lysosomal degradation in the RPE have been implicated in age-related retinal degeneration, yet the contribution of MITF to these pathways remains incompletely understood. Here, we show that reduced Mitf expression impairs autophagy in mouse and h...

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Literature Corpus work: 91fbb648-72e1-58b7-81e0-c24aba77b25b
DOI: 10.64898/2026.05.22.727222

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