Article

Lipopolysaccharide and Recombinant Prion Protein Induce Distinct Neurodegenerative Pathologies in FVB/N Mice

2025-04-14

Abstract excerpt

Prion diseases are typically attributed to the accumulation of protease-resistant prion protein (PrPSc), yet growing evidence indicates that alternative misfolded PrP conformers and inflammatory factors may also drive neurodegeneration. Whether bac-terial lipopolysaccharide (LPS) can independently generate or exacerbate prion-like pathology in the absence of classical PrPSc remains unclear. This study aimed to det...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5437cb8-2515-52d2-9f9c-e1d6349ee896
DOI: 10.20944/preprints202504.1132.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lipopolysaccharide and Recombinant Prion Protein Induce Distinct Neurodegenerative Pathologies in FVB/N MiceDOI 10.20944/preprints202504.1132.v1Read

LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface.Semantic proximity Read

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibrilSemantic proximity Read

Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype.Semantic proximity Read

Neuroprotective and neurotoxic signaling by the prion protein.Semantic proximity Read

Prions: generation and spread versus neurotoxicity.Semantic proximity Read

Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic NeurodegenerationSemantic proximity Read

Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal lossSemantic proximity Read

Prion pathogenesis in the absence of Toll‐like receptor signallingSemantic proximity Read

The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-synuclein: Intranasal LPS Exposure on the A53T-α-synuclein Transgenic Mouse Model of Parkinson's DiseaseSemantic proximity Read

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains, and endpointsSemantic proximity Read

Microglia depletion prior to lipopolysaccharide and paraquat treatment differentially modulates behavioral and neuronal outcomes in wild type and G2019S LRRK2 knock-in mice.Semantic proximity Read

High-resolution structure and strain comparison of infectious mammalian prions.Semantic proximity Read