Article
High-resolution structure and strain comparison of infectious mammalian prions.
Molecular cell - 4 Nov 2021
Kraus Allison, Hoyt Forrest, Schwartz Cindi L, Hansen Bryan, Artikis Efrosini, Hughson Andrew G, Raymond Gregory J, Race Brent, Baron Gerald S, Caughey Byron
Abstract excerpt
Within the extensive range of self-propagating pathologic protein aggregates of mammals, prions are the most clearly infectious (e.g., ∼109 lethal doses per milligram). The structures of such lethal assemblies of PrP molecules have been poorly understood. Here we report a near-atomic core structure of a brain-derived, fully infectious prion (263K strain). Cryo-electron microscopy showed amyloid fibrils assembled...
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