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Article

LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface.

Journal of neuroinflammation - 22 May 2017

Salvesen Ø, Reiten M R, Espenes A, Bakkebø M K, Tranulis M A, Ersdal C

Abstract excerpt

BACKGROUND: The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNP Ter/Ter) provides a novel model for studying PrPC physiology. METHODS: In order to explore putative roles for PrPC in acute inflammatory responses, we...

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Source

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Identifiers

PMID: 28532450
DOI: 10.1186/s12974-017-0879-5
PMCID: PMC5441080

Genes

PRNP
CXCL12
CXCL14
ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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