Article

RBPMS as a novel marker for cancer-associated fibroblasts in distinguishing left and right colorectal cancer sidedness

2025-08-07

Abstract excerpt

<h4>Background</h4> Colorectal cancer (CRC) can be classified into left-sided (LCRC) and right-sided CRC (RCRC). These CRC entities present different molecular phenotypes and prognosis. Accumulation of cancer-associated fibroblasts (CAFs) reflects poor prognosis and recurrence of CRC. CAF-cancer cell crosstalk regulates fibroblast activation and drives CRC progression, facilitated via secretomes including TGFβ1....

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Literature Corpus work: e5410c45-9147-569e-8f82-3f3fbbf521fe
DOI: 10.1101/2025.08.05.668832

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