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Integrated analysis of single cell and bulk RNA sequencing identifies CTHRC1+INHBA+CAF as drivers of colorectal cancer progression

4 Aug 2023

Abstract excerpt

Abstract Cancer‐associated fibroblasts (CAFs) are a key component of the tumor microenvironment and a critical factor in the progression of colorectal cancer (CRC). The aim of this study was to screen for CAFs specific genes that could serve as promising therapeutic targets for CRC patients. Our findings showed a significant increase in the proportion of fibroblasts in CRC tissues, and a high proportion of...

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PMID: 37539967
DOI: 10.1002/mc.23615

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