Article

A Comprehensive Multi-Omics Analysis Identifies a Robust Scoring System for Cancer-Associated Fibroblasts and Intervention Targets in Colorectal Cancer

2023-09-27

Abstract excerpt

<h4>Background: </h4> Cancer-associated fibroblasts (CAF) play a critical role in promoting tumor growth, metastasis, and immune evasion. While numerous studies have investigated CAF, there remains a paucity of research on their clinical application in colorectal cancer (CRC). Methods In this study, we collected differentially expressed genes between CAF and normal fibroblasts (NF) from previous CRC studies, and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8c0fa7e-a8a1-5728-b61f-0efb2edc916a
DOI: 10.21203/rs.3.rs-3341136/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Comprehensive Multi-Omics Analysis Identifies a Robust Scoring System for Cancer-Associated Fibroblasts and Intervention Targets in Colorectal CancerDOI 10.21203/rs.3.rs-3341136/v1Read

CAF signature predicts the prognosis of colorectal cancer patients: A retrospective study based on bulk RNA sequencing and single-cell RNA sequencing dataSemantic proximity Read

Redefining colorectal cancer classification and clinical stratification through a single-cell atlasSemantic proximity Read

The Impact of Cancer-Associated Fibroblasts on the Biology and Progression of Colorectal CarcinomasSemantic proximity Read

Functional Gene Signature Offers a Powerful Tool for Characterizing Clinicopathological Features and Depicting Tumor Immune Microenvironment of Colorectal CancerSemantic proximity Read

The landscape of cancer-associated fibroblasts in colorectal cancer liver metastasesSemantic proximity Read

Profiling Cancer-Associated Fibroblasts (CAFs) in Gastric Cancer and Development of a CAF-Based Prognostic Signature Using Integrated Single-Cell RNA Sequencing and TCGA AnalysisSemantic proximity Read

Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancerSemantic proximity Read

Refining colorectal cancer classification and clinical stratification through a single-cell atlasSemantic proximity Read

Single-Cell RNA Sequencing and Inferred Protein Activity Analysis Reveal a Distinct Tumor Phenotype in Early-Onset Colorectal Cancer PatientsSemantic proximity Read

Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysisSemantic proximity Read

RNA-seq and bulk RNA-seq data analysis of cancer-related fibroblasts (CAF) in LUAD to construct a CAF-based risk signatureSemantic proximity Read

Consensus clustering and development of a risk signature based on trajectory differential genes of cancer-associated fibroblast subpopulations in colorectal cancerSemantic proximity Read