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Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation

6 May 2020

Abstract excerpt

OBJECTIVE: To identify and characterize myeloid cell populations within the CSF of patients with MS and anti-myelin oligodendrocyte glycoprotein (MOG) disorder by high-resolution single-cell gene expression analysis. METHODS: Single-cell RNA sequencing (scRNA-seq) was used to profile individual cells of CSF and blood from 2 subjects with relapsing-remitting MS (RRMS) and one with anti-MOG disorder. Publicly...

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PMID: 32371549
DOI: 10.1212/nxi.0000000000000732

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