Article

MIC-MAC: High-throughput analysis of three-dimensional microglia morphology in mammalian brains

2018-08-10

Abstract excerpt

<h4>ABSTRACT</h4> Microglia, the resident immune cells of the brain, exhibit complex and diverse phenotypes depending on their physiological context including brain regions and disease states. While single-cell RNA-sequencing has recently resolved this heterogeneity, it does not capture tissue and intercellular mechanisms. Our complementary imaging-based approach enables automatic 3D-morphology characterization a...

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Literature Corpus work: 0d73fe0f-b96e-5b1b-9df4-8aeb4cf57606
DOI: 10.1101/388397

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