Article

Hydroxymethylated- <i>P16</i> Allele Is Transcription-Inactive

2018-08-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> 5-Methylcytosine can be oxidized into 5-hydroxymethylcytosine (5hmC) in the genome. Methylated- P16 (P16M) can be oxidized into completely hydroxymethylated- P16 (P16H) in human cancer and precancer cells. The aim of this study is to investigate the biological function of P16H. <h4>Methods</h4> True P16M and P16H were analyzed using bisulfite/TAB-based assays. A ZFP-base...

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Literature Corpus work: e5250ac2-0c98-5958-a606-5e9778e50cce
DOI: 10.1101/405522

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