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Article

Homeostatic maintenance of allele-specific p16 methylation in cancer cells accompanied by dynamic focal methylation and hydroxymethylation.

PloS one - 1 Jan 2014

Qin Sisi, Li Qiang, Zhou Jing, Liu Zhao-Jun, Su Na, Wilson James, Lu Zhe-Ming, Deng Dajun

Abstract excerpt

AIM: p16 Methylation frequently occurs in carcinogenesis. While it has been hypothesized that the p16 methylation states are dynamically maintained in cancer cells, direct evidence supporting this hypothesis has not been available until now. METHODS: A fusion cell model was established which reprogrammed the native DNA methylation pattern of the cells. The methylation status of the p16 alleles was then repeatedly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24828678
DOI: 10.1371/journal.pone.0097785
PMCID: PMC4020935

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