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Quantitative methylation analysis reveals gender and age differences in p16<scp>INK</scp>4a hypermethylation in hepatitis B virus‐related hepatocellular carcinoma

23 Dec 2011

Abstract excerpt

BACKGROUND: Frequent promoter hypermethylation of the inhibitors in either Rb or p53 pathways is associated with the hepatocellular carcinoma (HCC) development. OBJECTIVE: To quantitatively assess the gradual changes of the promoter methylation of p14ARF, p15INK4b, p16INK4a and CCND2 genes in hepatitis B virus (HBV) infection-related HCC. METHODS: A total of 118 pairs of tumour and their corresponding non-tumour...

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PMID: 22192146
DOI: 10.1111/j.1478-3231.2011.02696.x

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