Article

Interferon-stimulated genes in zebrafish and human define an ancient arsenal of antiviral immunity

2019-07-04

Abstract excerpt

The evolution of the interferon (IFN) system, the major innate antiviral mechanism of vertebrates, remains poorly understood. According to the detection of type I IFN genes in cartilaginous fish genomes, the system appeared 500My ago. However, the IFN system integrates many other components, most of which are encoded by IFN-stimulated genes (ISGs). To shed light on its evolution, we have used deep RNA sequencing t...

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Literature Corpus work: e5194ca9-20db-5f70-8f72-b37d78a9598c
DOI: 10.1101/693333

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