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Article

Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution.

BMC immunology - 5 May 2010

Huang Bei, Qi Zhi T, Xu Zhen, Nie Pin

Abstract excerpt

BACKGROUND: Interferon regulatory factors (IRFs), which can be identified based on a unique helix-turn-helix DNA-binding domain (DBD) are a large family of transcription factors involved in host immune response, haemotopoietic differentiation and immunomodulation. Despite the identification of ten IRF family members in mammals, and some recent effort to identify these members in fish, relatively little is known...

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Identifiers

PMID: 20444275
DOI: 10.1186/1471-2172-11-22
PMCID: PMC2885996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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