Article
Both STING and MAVS fish orthologs contribute to the induction of interferon mediated by RIG-I.
PloS one - 1 Jan 2012
Biacchesi Stéphane, Mérour Emilie, Lamoureux Annie, Bernard Julie, Brémont Michel
Abstract excerpt
Viral infections are detected in most cases by the host innate immune system through pattern-recognition receptors (PRR), the sensors for pathogen-associated molecular patterns (PAMPs), which induce the production of cytokines, such as type I interferons (IFN). Recent identification in mammalian and teleost fish of cytoplasmic viral RNA sensors, RIG-I-like receptors (RLRs), and their mitochondrial adaptor: the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
