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Article

Characterization of fish IRF3 as an IFN-inducible protein reveals evolving regulation of IFN response in vertebrates.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2010

Sun Fan, Zhang Yi-Bing, Liu Ting-Kai, Gan Li, Yu Fei-Fei, Liu Ying, Gui Jian-Fang

Abstract excerpt

In mammals, IFN regulatory factor (IRF) 3 is a critical player in modulating transcription of type I IFN and IFN-stimulated genes (ISGs). In this study, we describe the roles of crucian carp (Carassius auratus L.) IRF3 in activating fish IFN and ISGs. Fish IRF3 exhibits a large sequence divergenc...

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Source

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PMID: 21084665
DOI: 10.4049/jimmunol.1002401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21084665-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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