Article

Tissue Specific Requirement for the Inv(16) Oncogene <i>CBFB::MYH11</i> in Acute Myeloid Leukemia

2024-10-06

Abstract excerpt

Inversion of chromosome 16 [inv(16)] generates the fusion gene CBFB::MYH11 (CM) and is one of the most common chromosomal rearrangements in Acute Myeloid Leukemia (AML). Expression of CM is required for leukemia initiation. Patients with inv(16) at diagnosis invariably have the rearrangement at relapse, leading to the assumption that CM is also required after leukemic transformation. However, a role for CM in...

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Literature Corpus work: e4fbc8dc-6f59-57e7-9d26-62390046c4a0
DOI: 10.1101/2024.10.06.616896

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