Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice.

Cancer research - 1 Dec 2006

Heilman Susan A, Kuo Ya-Huei, Goudswaard Chantal S, Valk Peter J, Castilla Lucio H

Abstract excerpt

The gene encoding for core-binding factor beta (CBFbeta) is altered in acute myeloid leukemia samples with an inversion in chromosome 16, expressing the fusion protein CBFbeta-SMMHC. Previous studies have shown that this oncoprotein interferes with hematopoietic differentiation and proliferation and participates in leukemia development. In this study, we provide evidence that Cbfbeta modulates the oncogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Chromosome Inversion
Share to Chromosomes, Human, Pair 16

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Muscle, Smooth

Share to Myeloid Progenitor Cells

Share to Myosin Heavy Chains

Share to Oncogene Proteins, Fusion

Source

Identifiers

PMID: 17145866
DOI: 10.1158/0008-5472.CAN-06-0959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice.PMID 17145866Read ↗

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates.Semantic proximity Read ↗

RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia developmentSemantic proximity Read ↗

The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.Semantic proximity Read ↗

The core-binding factor leukemias: lessons learned from murine models.Semantic proximity Read ↗

Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.Semantic proximity Read ↗

Tissue Specific Requirement for the Inv(16) Oncogene <i>CBFB::MYH11</i> in Acute Myeloid LeukemiaSemantic proximity Read ↗

Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11.Semantic proximity Read ↗

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11Semantic proximity Read ↗

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.Semantic proximity Read ↗

Core binding factor and its role in normal hematopoietic developmentSemantic proximity Read ↗

CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)Semantic proximity Read ↗

The clinical mutatome of core binding factor leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.