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Article

Myb drives B-cell neoplasms and myeloid malignancies in vivo

16 May 2022

Abstract excerpt

The proto-oncogene MYB encodes the transcription factor c-MYB (cellular MYB, hereafter called MYB), which is often upregulated or aberrantly activated in cancer, including hematological malignancies.1,2 High Myb levels were especially found in acute myeloid leukemia (AML).2-4 Myb was identified initially as a retroviral oncogene (v-Myb) of avian myeloblastosis virus and E26.5,6 These retroviruses are able to...

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PMID: 35020834
DOI: 10.1182/bloodadvances.2021005955

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