Article
The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia.
The Journal of biological chemistry - 2 Dec 2005
Moreno-Miralles Isabel, Pan Ling, Keates-Baleeiro Jennifer, Durst-Goodwin Kristie, Yang Chunying, Kim Hyung-Gyoon, Thompson Mary Ann, Klug Christopher A, Cleveland John L, Hiebert Scott W
Abstract excerpt
The inv(16) is one of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML) and creates a chimeric fusion protein consisting of most of the runt-related X1 co-factor, core binding factor beta fused to the smooth muscle myosin heavy chain MYH11. Expression of the ARF tumor suppressor is regulated by runt-related X1, suggesting that the inv(16) fusion protein (IFP) may repress...
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